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Notice01-93062001-04-18

Notice of Denial of Petition

Justice Department, Drug Enforcement Administration

Action & Dates

Dates
July 2000, Edition Desc: 4th Edition--Text Revision. Dewey, W. L., Martin, B. R., May, E. L. Cannabinoid stereoisomers: pharmacological effects. In Smith, D. F. (Ed.) CRC Handbook of stereoisomers: drugs in psychopharmacology, 317-326 (Boca Raton, FL, CRC Press), 1984. Fried, P. A., Watkinson, B. 36- and 48-month neurobehabioral follow- up of children prenatally exposed to marijuana, cigarettes and alcohol. J. Dev. Behav. Pediatr. 1987, 8, 318-326. Fried, P. A., Watkinson, B., Gray, R. A follow-up study of attentional behavior in 6-year-old children exposed prenatally to marihuana, cigarettes and alcohol. Neurotoxicol. Teratol. 1992, 14, 299-311. Fried, P. A., Watkinson, B., Gray, R. Differential effects on cognitive functioning in 9- to 12-year olds prenatally exposed to cigarettes and marihuana. Neurotoxicol. Teratol. 1998, 20(3), 293- 306. French, E.D. Delta\9\-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors. Neurosci Lett 1997, 226, 159-162. Fung, M., Gallagher, C., Machtay, M. Lung and aeo-digestive cancers in young marijuana smokers. Tumori 1999, 85 (2), 140-142. Galiegui, S.; Mary, S.; Marchand, J.; Dussossoy, D.; Carriere, D.; Carayon, P.; Bouaboula, M; Shire, D.; Le Fur, g.; Casellas, P. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem. 1995, 232(1), 54-61. Gaoni, Y., Mechoulam, R. Isolation, structure, and partial synthesis of an active constituent of hashish. J. Am. Chem. Soc. 1964, 86, 1646-1947. Gerard, C. M., Mollereau, C., Vassart, G., Parmentier, M. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. : Biochem J. 1991, 279, 129-34. Gessa, G.L., Melis, M., Munoni, A.L., Diana, M. Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors. Eur J Pharmacol 1998, 341(1), 39-44. Graham, J.D.P., ed. Cannabis and Health. New York: Academic Press, 1976. Griffith, D. R., Azuma, S. D., Chasnoff, I. J. Three-year outcome of children exposed prenatally to drugs. J. Am. Acad. Child Adolesc. Psychiatry 1994, 33, 20-27. Haney M, Ward AS, Comer SD, Foltin RW, Fischman MW. Abstinence symptoms following smoked marijuana in humans. Psychopharmacology (Berl) 1999, 141(4):395-404. Hanus, L., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R.G., Roos, R. A., Mechoulam, R., Fride, E. HU-308: a specific agonist for CB(2), a peripheral Cannabinoid receptor. Proc. Natl. Acad. Sci. USA 1999, 96, 14228-33. Harvey, D.J., ed. Satellite Symposium on Cannabis (3rd: 1984: Oxford, England) Marihuana '84: Proceedings of the Oxford Symposium on Cannabis. Washington, DC: IRL Press, 1985. Herkenham, M. Cannabinoid receptor localization in brain: Relationship to motor and reward systems. In: Kalivas, P.W., and Samson, H.H., eds. The neurobiology of drug and alcohol addiction. Ann N Y Acad Sci 1992, 654, 19-32. Herkenham, M., Lynn, A.B., Little, M.D., Johnson, M.R., Melvin, L.S., de Costa, B.R., Rice, K.C. Cannabinoid receptor localization in Brain. Proc. Natl. Acad. Sci. USA. 1990, 87, 1932-1936. Herning, R.I.; Hooker, W.D.; and Jones, R.T. Tetrahydrocannabinol content and differences in marijuana smoking behavior. Psychopharmacology 1986, 90(2):160-162. Hively, R.L., Mosher, W.A., Hoffman, F.W. Isolation of trans-)9- tetrahydrocannabinol from marihuana. J. Am. Chem. Soc. 1966, 88, 1832-1833. Hollister, L.E. Health aspects of cannabis. Pharmacological Rev. 1986, 38, 1-20. Hollister, L.E. Cannabis. (Literature review). Acta Psychiatr Scand (Suppl) 1988, 78, 108-118. Huestis, M.A., Sampson, A.H., Holicky, B.J., Henningfield, J.E., Cone, E.J. Characterization of the absorption phase of marijuana smoking. Clin. Pharmacol. Ther. 1992a, 52, 31-41. Huestis, M.A.; Henningfield, J.E.; and Cone, E.J. Blood Cannabinoids. 1. Absorption of THC and formation of 11- OH-THC and THC COOH during and after smoking marijuana. J Anal Toxicol 1992b, 16(5), 276-282. Johansson, E.; Halldin, M.M.; Agurell, S.; Hollister, L.E.; and Gillespie, H.K. Terminal elimination plasma half-life of delta 1- tetrahydrocannabinol (delta 1-THC) in heavy users of marijuana. Eur J Clin Pharmacol 1989, 37(3), 273-277. Jones, R.T.; Benowitz, N.L.; and Herning, R.I. Clinical relevance of cannabis tolerance and dependence. J Clin Pharmacol 1981, 21,143S- 152S. Koob, G.F. Neural mechanisms of drug reinforcement. Ann. N Y Acad Sci 1992, 654, 171-191. Lane JD, Phillips-Bute BG. Caffeine deprivation affects vigilance performance and mood. Physiol Behav 1998 65, 171-5. Lemberger L., Rubin A. The physiologic disposition of marihuana in man, Life Sci. 1975,17, 1637-42. Lemberger L., Silberstein, S.D., Axelrod, J., Kopin, I.J. Marihuana: studies on the disposition and metabolism of delta-9- tetrahydrocannabinol in man. Science 1970, 170, 1320-1322. Lemberger L., Weiss, J.L., Watanabe, A.M., Galanter, I.M., Wyatt, R.J., Cardon, P. V. Delta-9-tetrahydrocannabinol: temporal correlation of the psychological effects and blood levels after various routes of administration. New Eng. J. Med. 1972a, 286(13), 685-688. Lemberger, L., Crabtree, R.E., Rowe, H.M. 11-Hydroxy-)<SUP>9</SUP>- tetrahydrocannabinol: pharmacology, disposition and metabolism of a major metabolite of marihuana in man. Science 1972b, 177, 62-63. Martin, B.R.; Mechoulam, R., Razdan, R.K. Discovery and characterization of endogenous cannabinoids. Life Sci. 1999, 65, 573-595. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C., Bonner, T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990, 346, 561-564. Mechoulam, R. Cannabinoid chemistry. In Mechoulam, R. (ED.) Marijuana, pp.2-88 (New York, NY, Academic Press, Inc.), 1973. Monitoring the Future. National Results on Adolescent Drug Use. Overview of 1999 Key findings, 1999. Department of Health and Human services. National Institute on Drug Abuse. Rockville, MD. (http:// monitoringthefuture.org) National Institutes of Health (NIH). Workshop on the medical Utility of Marijuana, February 19-20, 1997. (www.nih.gov/news/medmarijuana/ MedicalMarijuana.htm) NHSDA. Summary of Findings from the 1999 National Household Survey on Drug Abuse. Office of Applied Studies. Department of Health and Human services. Substance Abuse and Mental Health Services Administration. National Clearinghouse for Alcohol and Drug information. Rockville, MD. Office of National Drug Control Policy. The National Drug Control Strategy: 2000 Annual Report. Superintendent of Documents, Mail Stop: SSOP, Washington, DC. Oviedo, A., Glowa, J., Herkenham, M. Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study. Brain Res. 1993, 616, 293-302. Rinaldi-Carmona, M., Barth F., Heaulme, M., Shire, D., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Letters 1994, 350, 240-244. Rinaldi-Carmona M, Barth F, Millan J, Derocq JM, Casellas P, Congy C, Oustric D, Sarran M, Bouaboula M, Calandra B, Portier M, Shire D, Breliere JC, Le Fur GL, SR 144528, the first potent and selective antagonist of the CB<INF>2</INF> cannabinoid receptor. J Pharmacol Exp Ther. 1998 , 284(2), 644-50. Rodriguez de Fonseca F, Gorriti, M.A., Fernandez-Ruiz, J.J., Palomo, T., Ramos, J.A. Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinoil treatment. Phamacol. Biochem. Behav. 1994, 47 (1), 33-40. Ross, S.A. and ElSohlyy, M.A. Constituents of Cannabis Sativa L. XXVIII. A review of the natural constituents:1980-1994. Zagazig J. Pharm. Sci. 1995, 4 (2), 1-10. Sanudo-Pena M.C., Tsou, K., Delay, E.R., Hohman, A.G., Force, M., Walker, J.M. Endogenous cannabinoids as an aversive or counter- rewarding system in the rat. Neurosci. Lett., 223, 125-128, 1997. Treatment Episode Data Set (TEDS): 1993-1998. National Admissions to Substance Abuse Treatment Services. Department of Health and Human services. Substance Abuse and Mental Health Services Administration. National Clearinghouse for Alcohol and Drug information. Rockville, MD. Wesson, D.R.; Washburn, P. Current patterns of drug abuse that involve smoking. In Research Findings on Smoking of Abused Substances, Chiang, C.N.; Hawks, R.L. (ED.) NIDA Research Monograph, 99:5-11, 1990.
Effective Date
1997-02-19

Document Excerpt

Document Headings Document headings vary by document type but may contain the following: the agency or agencies that issued and signed a document the number of the CFR title and the number of each part the document amends, proposes to amend, or is directly related to the agency docket number / agency internal file number the RIN which identifies each regulatory action listed in the Unified Agenda of Federal Regulatory and Deregulatory Actions See the Document Drafting Handbook for more details. Department of Justice Drug Enforcement Administration By letter dated March 20, 2001, the Drug Enforcement Administration (DEA) denied a petition to initiate rulemaking proceedings to reschedule marijuana. Because DEA believes that this matter is of particular interest to members of the public, the agency is publishing below the letter sent to the petitioner (denying the petition), along with the supporting documentation that was attached to the letter. Basis for the Recommendation for Maintaining Marijuana in Schedule I of the Controlled Substances Act A. Background On July 10, 1995, Mr. Jon Gettman submitted a petition to the Drug Enforcement Administration (DEA) requesting that proceedings be initiated to repeal the rules and regulations that place marijuana and the tetrahydrocannabinols in Schedule I of the Controlled Substances Act (CSA) and dronabinol and nabilone in Schedule II of the CSA. The petition contends that evidence of abuse potential is insufficient for each substance or class of substances to be controlled in Schedule I or II of the CSA. In December 1997, the DEA Administrator requested that the Department of Health and Human Services (DHHS) develop scientific and medical evaluations and recommendations as to the proper scheduling of the substances at issue, pursuant to 21 U.S.C. 811(b) . This document responds to the portion of the petition that concerns marijuana * * *. In accordance with 21 U.S.C. 811(b) , the DEA has gathered information, and the Secreta

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Citation: 66 FR 20038